Lung surfactant market plays a crucial role in the functioning of the organ by reducing surface tension in alveolar cells, which helps stabilize the alveoli and prevents pulmonary edema. Currently, both naturally derived and synthetic surfactants are being utilized to treat neonatal Respiratory Distress Syndrome (RDS), a leading cause of mortality among premature infants. Surfactant is recommended for preventive therapy in infants weighing less than 1,350 g or 3 lb, as well as for rescue therapy in infants with respiratory distress syndrome.
Furthermore, lung surfactants are employed in the prevention and treatment of RDS in neonates. RDS is a significant complication resulting from premature birth and affects approximately 40,000 infants annually in the United States and Canada. Insufficient surfactant, either functionally or quantitatively, leads to reduced lung compliance and eventual lung collapse. Surfactant, composed of phospholipids, neutral lipids, and proteins produced by pneumocytes during gestation, effectively lowers surface tension, thereby stabilizing the alveoli, increasing lung compliance, and alleviating respiratory difficulties.
Researchers are exploring the use of mammalian, human, and artificial surfactants for premature infants. Controlled trials of exogenous surfactant therapy have demonstrated reduced mortality rates, decreased air-leakage in the lungs, and improved gas exchange. While surfactant has negligible toxicity, there is a potential for immunogenicity. Overall, surfactant is a safe investigational agent that holds promise for the prevention and treatment of neonatal RDS, thus expanding the opportunities within the lung surfactants market.
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Lung Surfactants Market: Competitive Landscape
This section of the report enlists various leading manufacturers of the market. It helps the investors comprehend the strategies and collaborations that market players are focusing on to garner an edge over the competition in the industry. The comprehensive report provides a significant dissection of the market. Market footprints of manufacturers are identified by observing the global revenue of manufacturers, the global presence of manufacturers, and sales by manufacturers during the 2017 to 2027 forecast period.
Key Players in Lung Surfactants Market
- Chiesi Farmaceutici
- Lyomark Pharma
- AbbVie
- ONY Biotech
- Aviva Systems Biology Corporation
- Windtree Therapeutics
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Driving Factors of the Lung Surfactants Market:
- Rising prevalence of respiratory disorders: The increasing incidence of respiratory disorders, such as neonatal respiratory distress syndrome (RDS) and acute respiratory distress syndrome (ARDS), is a major driving factor for the lung surfactants market. These conditions require surfactant therapy for effective treatment.
- Growing premature birth rates: Premature birth is a significant risk factor for respiratory complications in infants, including RDS. With the rising number of premature births worldwide, the demand for lung surfactants has increased, driving market growth.
- Technological advancements in surfactant formulations: Continuous research and development efforts have led to the development of advanced surfactant formulations with improved efficacy and safety profiles. These technological advancements have expanded the treatment options available and have positively influenced market growth.
- Increasing healthcare expenditure: The rising healthcare expenditure in many countries, particularly in developing regions, has improved access to healthcare facilities and advanced treatment options. This has contributed to the growing adoption of surfactant therapy, driving the market for lung surfactants.
Restraints of the Lung Surfactants Market:
- High cost of surfactant therapy: Lung surfactant therapy can be expensive, especially for individuals with limited financial resources. The high cost of surfactant products and associated healthcare services may limit their accessibility, particularly in lower-income regions, thereby restraining market growth.
- Lack of awareness and infrastructure in developing regions: In some developing regions, there is a lack of awareness about the importance of surfactant therapy and limited healthcare infrastructure to support its administration. These factors can hinder the adoption of lung surfactants and impede market growth.
- Stringent regulatory requirements: The lung surfactants market is subject to strict regulatory requirements and approvals, which can create barriers for new entrants and hinder the introduction of innovative products. Compliance with regulatory standards can be time-consuming and costly, affecting market growth.
- Potential side effects and complications: Although surfactant therapy is generally considered safe, there can be potential side effects and complications associated with its use, such as lung injury, infection, and immunogenic reactions. These concerns may impact the confidence of healthcare providers and patients, limiting the market's expansion.
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