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Tramadol relieves pain somewhat quickly, yet the formulation affects when it starts to work: Immediate-release tablets: These usually begin to act in 30 to 60 minutes and reach their peak effects in about two hours. Extended-release pills: Made to control pain for a longer period of time, these tablets may take longer to start working but offer consistent relief for 12 to 24 hours. Individual characteristics like as age, metabolism, and medical problems can affect how rapidly Tramadol acts. For greatest benefits, it is best to adhere to the recommended timetable. How Effective Is Tramadol for Treating Pain? One common prescription medication that works well for mild to fairly severe pain is tramadol. It functions by going after the brain’s pain receptors and amplifying the effects of neurotransmitters that regulate pain, such as serotonin and norepinephrine. Acute pain relief: Often recommended for pain following surgery or an injury. 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