Sphingosine-1-phosphate (S1P) is a bioactive lipid produced by sphingolipid metabolism and is involved in a variety of basic cellular functions, such as cell proliferation, migration, survival, and intercellular signaling. S1P can be produced intracellularly by sphingosine catalyzed by specific sphingosine kinase (SphK), but can also be catabolized by S1P phosphatase or S1P lyase (S1PL),...
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