How much Benadryl can I give my dog? - When considering giving Benadryl to your dog, it's essential to consult with a veterinarian to ensure proper dosage and suitability for your specific dog. The dosage of Benadryl for dogs depends on their size, weight, and individual health conditions. Typically, the recommended dosage is 1 mg of Benadryl per pound of body weight, given two to three times a day. However, it's crucial to follow your veterinarian's advice and never administer any medication to your dog without their guidance and approval.