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It is often prescribed for conditions such as arthritis (inflammations of joints), fibromyalgia (widespread muscle pain and tenderness), and post-operative pain. Tramadol functions by binding to opioid receptors in the brain and preventing the reabsorption of norepinephrine and serotonin, which helps change how the brain perceives pain. The extended-release form of Tramadol is prescribed for patients who require continuous pain relief over an extended period, such as those with chronic pain syndrome. How does Tramadol Work? Tramadol works by interacting with certain receptors in the brain to help reduce pain. It is a synthetic opioid that acts on the μ-opioid receptors, which are responsible for decreasing pain perception. Tramadol also affects the levels of serotonin and norepinephrine, two chemicals in the brain that help regulate pain. By blocking the reuptake of these chemicals, tramadol enhances their effects, which further helps in reducing pain. This dual action—activating opioid receptors and boosting the activity of serotonin and norepinephrine—makes tramadol effective in managing different types of pain, from short-term to long-term. Efficacy Tramadol’s effectiveness in relieving pain can differ from person to person. Some people may get strong pain relief from tramadol, while others might not find it as helpful. How well tramadol works can depend on the type and level of pain, how a person’s body processes the medication, and whether they have other health conditions or are taking other medications that might affect tramadol. Why Do Doctor Prescribe Tramadol? Doctors prescribe Tramadol primarily for the following purposes: Pain Relief: Tramadol is a medication used to manage moderate to moderately severe pain. It works by altering how your brain perceives and responds to pain. 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